Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome

Serena Vita,Virginia Di Bari,Angela Corpolongo,Delia Goletti,Joaquin Espinosa, Sebastiano Petracca,Fabrizio Palmieri,Emanuele Nicastri, Maria Alessandra Abbonizio,Chiara Agrati,Fabrizio Albarello, Gioia Amadei,Alessandra Amendola,Mario Antonini, Raffaella Barbaro,Barbara Bartolini, Martina Benigni,Nazario Bevilacqua,Licia Bordi,Veronica Bordoni, Marta Branca,Paolo Campioni,Maria Rosaria Capobianchi, Cinzia Caporale, Ilaria Caravella,Fabrizio Carletti,Concetta Castilletti,Roberta Chiappini, Carmine Ciaralli,Francesca Colavita,Massimo Cristofaro,Salvatore Curiale,Alessandra D’Abramo, Cristina Dantimi, Alessia De Angelis,Giada De Angelis, Rachele Di Lorenzo,Federica Di Stefano,Federica Ferraro, Lorena Fiorentini,Andrea Frustaci,Paola Gallì,Gabriele Garotto,Maria Letizia Giancola,Filippo Giansante,Emanuela Giombini,Maria Cristina Greci,Giuseppe Ippolito,Eleonora Lalle,Simone Lanini,Daniele Lapa,Luciana Lepore, Andrea Lucia, Franco Lufrani, Manuela Macchione,Alessandra Marani,Luisa Marchioni,Andrea Mariano,Maria Cristina Marini,Micaela Maritti,Giulia Matusali,Silvia Meschi, Francesco Messina Chiara Montaldo, Silvia Murachelli, Roberto Noto,Claudia Palazzolo, Emanuele Pallini, Virgilio Passeri, Federico Pelliccioni, Antonella Petrecchia,Ada Petrone,Nicola Petrosillo,Elisa Pianura, Maria Pisciotta,Silvia Pittalis, Costanza Proietti,Vincenzo Puro, Gabriele Rinonapoli,Martina Rueca,Alessandra Sacchi, Francesco Sanasi, Carmen Santagata, Silvana Scarcia,Vincenzo Schininà,Paola Scognamiglio,Laura Scorzolini, Giulia Stazi,Francesco Vaia,Francesco Vairo,Maria Beatrice Valli

International Journal of Infectious Diseases（2021）

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摘要

•Pro-inflammatory factors play a central role in COVID-19 severity and mortality.•Down Syndrome is characterised by immune dysregulation and respiratory infections.•Down Syndrome patients with COVID-19 are at high risk of an unfavourable outcome.

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关键词

COVID-19 pneumonia,Down syndrome,Immune dysregulation,Immune activation

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