Lactoferrin promotes osteogenesis of MC3T3-E1 cells induced by mechanical strain in an extracellular signal–regulated kinase 1/2–dependent manner

Li Huang,Zhenjin Yang,Ruojing Liu,Xiaoyue Xiao,Chenchen Zhou,Xing Yin,Shujuan Zou,Jianwei Chen

American Journal of Orthodontics and Dentofacial Orthopedics（2021）

引用 3|浏览15

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摘要

•Mechanical strain induced osteogenesis in nontransformed osteoblastic cells.•Lactoferrin (LF) corroborated the osteogenic effects of the mechanical strain of cells.•U0126 blocked the effect of LF and mechanical strain on cells.•LF promotes osteogenesis induced by strain in an Erk1/2-dependent manner.

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