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A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib As a Candidate for Rapid Repurposing for Acute Lung Injury

Maria Kost-Alimova,Eriene-Heidi Sidhom,Abhigyan Satyam,Brian T. Chamberlain,Moran Dvela-Levitt,Michelle Melanson,Seth L. Alper,Jean Santos,Juan Gutierrez,Ayshwarya Subramanian,Patrick J. Byrne,Elizabeth Grinkevich,Estefania Reyes-Bricio,Choah Kim,Abbe R. Clark,Andrew J. B. Watts,Rebecca Thompson,Jamie Marshall,Juan Lorenzo Pablo,Juliana Coraor,Julie Roignot,Katherine A. Vernon,Keith Keller,Alissa Campbell,Maheswarareddy Emani,Matthew Racette,Silvana Bazua-Valenti,Valeria Padovano,Astrid Weins,Stephen P. McAdoo,Frederick W. K. Tam, Luciene Ronco,Florence Wagner,George C. Tsokos,Jillian L. Shaw,Anna Greka

Cell Reports Medicine（2020）

Cited 50|Views64
Key words
MUC1,acute respiratory distress syndrome,ARDS,acute lung injury,ALI,fostamatinib,drug repurposing,COVID-19,SARS-CoV-2
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