Resource Allocation in Two-Patch Epidemic Model with State-Dependent Dispersal Behaviors Using Optimal Control

PROCESSES(2020)

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摘要
A two-patch epidemic model is considered in order to assess the impact of virtual dispersal on disease transmission dynamics. The two-patch system models the movement of individuals between the two-patches using a residence-time matrix P, where P depends on both residence times and state variables (infected classes). In this work, we employ this approach to a general two-patch SIR model in order to investigate the effect of state dependent dispersal behaviors on the disease dynamics. Furthermore, optimal control theory is employed to identify and evaluate patch-specific control measures aimed at reducing disease prevalence at a minimal cost. Optimal policies are computed under various dispersal scenarios (depending on the different residence-time matrix configurations). Our results suggest there is a reduction of the outbreak and the proportion of time spent by individuals in a patch exhibits less fluctuations in the presence of patch-specific optimal controls. Furthermore, the optimal strategies for each patch differ depending on the type of dispersal behavior and the different infection rate in a patch. In all of our results, we obtain that the optimal strategies reduce the number of infections per patch.
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关键词
two-patch model with virtual dispersal,the basic reproduction number,final epidemic size,optimal control interventions
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