EFFECTS OF AN AEROBIC PHYSICAL EXERCISE SESSION ON INFLAMMATORY MARKERS IL-6, IL-10 AND TNF-alpha IN PATIENTS WITH CHRONIC RENAL DISEASE (DRC) STAGE 3.

Introduction Loss of renal function results in serum accumulation of toxic substances in chronic kidney disease (CKD) patients. These substances increase the inflammatory response, which in turn contributes to the pathophysiology of cardiovascular disease in this population. It has been described in the general population that aerobic physical exercise is capable of exerting anti-inflammatory effects. However, the impact of physical exercise in CKD stage 3 patients (CKD3; creatinine clearance 29–69 ml/min) is unclear. Thus, the objective of this study was to evaluate the effects of a session of aerobic exercise on inflammation markers in CKD stage 3 patients. Methods 10 subjects with CKD3, (55 ± 6 years, creatinine clearance between 29 and 69 ml/min/1.73 m2), and 10 subjects with normal renal function (51 ± 5 years creatinine clearance> 100 ml/min/1.73m2) were selected to performed aerobic exercise (cycle ergometer, 45 min, 50% VO2peak). Before and after the sessions, blood samples were collected for analysis of the inflammatory markers: TNF-alpha, IL-6 and IL-10. Statistical analysis The normality of the data was tested by the Shapiro-Wilk test. Data were compared through two-factor ANOVA (groups × times) for parametric data, and the FRIEDMAN test used for non-parametric comparisons. A significant difference was considered when p <0.05. The software used was IBM SPSS STATISTICS 24.0. Results Aerobic physical exercise reduced IL-6 levels in the CKD3 group (2.13 ± 0.36 vs. 1.86 ± 0.45; p = 0.04). IL-10 levels increased after an aerobic exercise session compared to the control group (p <0.001). Physical exercise had no effect on TNF-alpha levels (P> 0.05). Conclusion When compared CKD3 with healthy individuals, patients with CKD3 are more inflamed. However, in this study the aerobic exercise decreased IL-6 (pro-inflammatory) and increased IL-10 (anti-inflammatory) in these patients. In conclusion, aerobic physical exercise played an anti-inflammatory effect in CKD stage 3 patients, suggesting that this practice may to benefit this population. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.