Hydatidiform mole diagnostics using circulating gestational trophoblasts isolated from maternal blood.

Lone Sunde,Ripudaman Singh,Katarina Ravn,Palle Schelde,Estrid Staehr Hansen,Niels Uldbjerg,Isa Niemann,Lotte Hatt

Molecular genetics & genomic medicine（2020）

引用 3|浏览14

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摘要

Our results show that it is possible to isolate and analyze circulating gestational trophoblasts originating in a pregnancy without maternal nuclear genome. For diagnosing gestational trophoblastic diseases, genotyping circulating gestational trophoblasts appears to be superior to analysis of cell-free DNA.

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关键词

androgenetic,cell-free nucleic acids,circulating neoplasm cells,diploidy,genotyping techniques,gestational trophoblastic disease,hydatidiform mole,liquid biopsy,other circulating cells

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