Protective effect of nerolidol on lipopolysaccharide-induced acute lung injury through the inhibition of NF-κB activation by the reduction of p38 MAPK and JNK phosphorylation

•Nerolidol suppressed proinflammatory responses in LPS-induced ALI mice.•Nerolidol inhibited phosphorylation of NFκB p65 in LPS-treated mice.•Nerolidol inhibited phosphorylation of p38 MAPK, JNK, ERK in LPS-treated mice.•Inhibition of NF-κB p65, p38 MAPK and JNK was similar to anti-inflammation.•Nrolidol acting as a protective reagent in LPS-induced ALI mice.