[Exhaustion of CD8 + T cell immune functions in spleen of mice with different doses of Echinococcus multilocularis infections].

may be killed and eliminated through the host immune responses at the middle and late stages of low- and medium-dose protoscolece infections, while high-dose protoscolece infections may trigger the upregulation of 2B4 expression in mouse spleen CD8 T cells at the late stage, which leads to immune exhaustion and the resultant chronic infections.