Randomised phase II trial of capecitabine plus oxaliplatin with continuous versus intermittent use of oxaliplatin as adjuvant chemotherapy for stage II/III colon cancer (CCOG-1302 study)

Goro Nakayama,Nao Takano,Hiroya Taniguchi,Kiyoshi Ishigure,Hiroyuki Yokoyama,Hitoshi Teramoto,Ryoji Hashimoto,Mitsuru Sakai,Akiharu Ishiyama,Takashi Kinoshita,Naomi Hayashi,Masanori Nakamura,Norifumi Hattori,Yusuke Sato,Shinichi Umeda, Kei Uehara,Toshisada Aiba,Fuminori Sonohara,Masamichi Hayashi,Mitsuro Kanda

European Journal of Cancer（2021）

引用 3|浏览30

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摘要

•This study was the first to evaluate adjuvant capecitabine plus oxaliplatin (CAPOX) with intermittent oxaliplatin for colon cancer.•Intermittent CAPOX reduced long-lasting peripheral sensory neuropathy compared with standard continuous CAPOX.•The efficacy of intermittent CAPOX was consistent with standard continuous CAPOX.

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关键词

Colon cancer,Adjuvant chemotherapy,Oxaliplatin,Peripheral sensory neuropathy,Randomised study

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