Transcriptomic Profiles in Pulmonary Arterial Hypertension Associate with Disease Severity and Identify Novel Candidate Genes
Pulmonary circulation(2020)
摘要
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
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关键词
pulmonary arterial hypertension,transcriptome profiling,PBMC,RNAseq
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