Glutathione S-Transferases CYP2C9 and CYP2C19 Polymorphisms in Turkish Children with Cancer

We investigated the associations between GSTM1, GSTT1, GSTP1, CYP2C9, CYP2C19 polymorphisms and childhood cancer. Genotypes were analyzed with real-time PCR in 61 children with cancer and 157 healthy controls. Twenty nine of 61 patients were diagnosed of leukemia and 8 of lymphoma. The remaining patients had solid tumors. GSTM1 null genotype was associated with an increased risk of leukemia and lymphoma (OR= 2.2, 95%CI= 1.1-4.6) (p= 0.03). Presence of at least one mutant allele of GSTP I was related to an increased risk of solid tumor (OR= 3.3, 95%CI= 1.3-8.3) (p= 0.02). Moreover, CYP2C9*2 allele was a high risk for leukemia and lymphoma (p= 0.04). In conclusion, GSTM1, GSTP1, and CYP2C9 polymorphisms may play a role in the development of childhood cancer.