Programmed Death Ligand 1 and Immune Cell Infiltrates in Solitary Fibrous Tumors of the Pleura

Luis F Tapias,Mari Mino-Kenudson,Edwin Choy,Marina Kem,Ashok Muniappan,Henning A Gaissert,Cameron D Wright,Harald C Ott,Douglas J Mathisen,Michael Lanuti

The Annals of Thoracic Surgery（2021）

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摘要

A small subset of SFTPs express PD-L1 at low levels (<1%) but exhibit colocalization of CD8 immune cells suggesting an inducible expression mechanism. The role of PD-L1 merits exploration in the clinical setting in patients with advanced SFTP when considering alternative treatments or clinical trials.

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关键词

Immunotherapy,Pleura,Pleural neoplasm,Pleural solitary fibrous tumor

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