Diffusivity in Breast Malignancies Analyzed for B > 1000 S/mm2 at 1 Mm In-Plane Resolutions: Insight from Gaussian and Non-Gaussian Behaviors.

Diffusion-weighted imaging (DWI) can improve breast cancer characterizations, but often suffers from low image quality -particularly at informative b > 1000 s/mm(2) values. The aim of this study was to evaluate multishot approaches characterizing Gaussian and non-Gaussian diffusivities in breast cancer. This was a prospective study, in which 15 subjects, including 13 patients with biopsy-confirmed breast cancers, were enrolled. DWI was acquired at 3 T using echo planar imaging (EPI) with and without zoomed excitations, readout-segmented EPI (RESOLVE), and spatiotemporal encoding (SPEN); dynamic contrast-enhanced (DCE) data were collected using three-dimensional gradient-echo T-1 weighting; anatomies were evaluated with T-2-weighted two-dimensional turbo spin-echo. Congruence between malignancies delineated by DCE was assessed against high-resolution DWI scans with b-values in the 0-1800 s/mm(2) range, as well as against apparent diffusion coefficient (ADC) and kurtosis maps. Data were evaluated by independent magnetic resonance scientists with 3-20 years of experience, and radiologists with 6 and 20 years of experience in breast MRI. Malignancies were assessed from ADC and kurtosis maps, using paired t tests after confirming that these values had a Gaussian distribution. Agreements between DWI and DCE datasets were also evaluated using Sorensen-Dice similarity coefficients. Cancerous and normal tissues were clearly separable by ADCs: by SPEN their average values were (1.03 +/- 0.17) x 10(-3) and (1.69 +/- 0.19) x 10(-3) mm(2)/s (p < 0.0001); by RESOLVE these values were (1.16 +/- 0.16) x 10(-3) and (1.52 +/- 0.14) x 10(-3) (p = 0.00026). Kurtosis also distinguished lesions (K = 0.64 +/- 0.15) from normal tissues (K = 0.45 +/- 0.05), but only when measured by SPEN (p = 0.0008). The best statistical agreement with DCE-highlighted regions arose for SPEN-based DWIs recorded with b = 1800 s/mm(2) (Sorensen-Dice coefficient = 0.67); DWI data recorded with b = 850 and 1200 s/mm(2), led to lower coefficients. Both ADC and kurtosis maps highlighted the breast malignancies, with ADCs providing a more significant separation. The most promising alternative for contrast-free delineations of the cancerous lesions arose from b = 1800 s/mm(2) DWI. Level of Evidence 2. Technical Efficacy Stage 3.