Recent Advances In Metal-Catalyzed Heterocyclic C-P Bond Formation

The heterocycles are important skeletons of many drugs, natural compounds and chemicals, and it also widely serves as building blocks in organic chemistry [1-7]. Remarkably, more than 85% of the drugs currently available contain at least one heterocyclic ring in their structures [8]. The organophosphorus of heterocycles units present as an important structural motif in natural products, organic ligands, pesticides and medicinal chemistry [9-11]. Owing to their wide structural diversity and peculiar properties, phosphorus-containing heterocycle compounds have attracted considerable attention in synthesis [12-17] (Scheme 1). Given the significance of organophosphorus of heterocycle compounds, it is particularly urgent to develop efficient and lesstoxic new synthetic methods for the synthesis of organophosphorus of heterocycles [18-21]. Hence, the highly efficient construction of these skeletons is one of the most important themes in organic synthesis. Traditional synthetic methods C-P of heterocycles bond heavily depending on the reaction of Arbuzov, Michaelis-BeckerABSTRACT The phosphorus-containing heterocycles are an important class of compounds in organic chemistry. Because of their potential application in many fields, especially, the synthetic pesticides, medicine and catalyst, the phosphorus-containing heterocycles have attracted continuous attention from organic synthesis scientists. The development of efficient and low-cost catalytic systems is of great interest for the construction of heterocycles C-P bond. Usually, the phosphorus-containing heterocycles is prepared via direct carbon-hydrogen (C-H) bond activation or pre-functionalized of heterocycles with phosphorus-hydrogen (P-H) bond of phosphorus compounds reaction by metal-catalyzed. This review summarizes recent progress in the heterocycles C-P bond formation reactions by metal-catalyzed, which mainly focus on the discussion of the reaction mechanism. It aims to provide efficient methods for the future synthesis and application in this field.