Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats

Kazufumi Nakamura,Satoshi Akagi,Kentaro Ejiri,Masashi Yoshida,Toru Miyoshi,Masakiyo Sakaguchi,Naofumi Amioka, Luh Oliva Saraswati Suastika,Megumi Kondo,Rie Nakayama,Yoichi Takaya,Yuichiro Higashimoto,Kei Fukami,Hiromi Matsubara,Hiroshi Ito

Journal of Cardiology（2021）

引用 5|浏览31

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摘要

•RAGE-aptamer suppresses development of monocrotaline-induced pulmonary arterial hypertension (PAH) in rats.•Inhibition of RAGE ameliorates muscularization of small pulmonary arteries.•Treatment with RAGE-aptamer might be a new therapeutic option for PAH.

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关键词

Pulmonary artery smooth muscle cells,Receptor for advanced glycation end products,Aptamer

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