ALA54THR POLYMORPHISM OF THE FABP2 GENE AND METABOLIC SYNDROME IN THE YAKUT POPULATION

The metabolic syndrome represents complex of the metabolic risk factors connected with increase in prevalence of diabetes and cardiovascular diseases. Each component of metabolic syndrome to some extent has communication with heredity that demonstrates that genetic factors can have significant effect on pathogenesis of this syndrome. In researches among some populations the association of polymorphism Ala54Thr of gene of FABP2 (rs1799883) with metabolic violations was shown. We analyzed association of allelic rs1799883 options (FABP2) with metabolic syndrome and its components at representatives of the Yakut ethnic group (on self-determination) from Berdigestyakh village of the Gorniy region of Republic Sakha (Yakutia). All surveyed people the written informed consent to participation in research. The program of research included screening by uniform technique on detection metabolic risk factors of chronic noncommunicable diseases. Polymerase chain reaction in real time was carried out in the CFX96 system of production Bio-Rad. Tests and primers were developed by means of the Beacon Designer 8 program from PREMIER Biosoft. From 228 participants of 42% had the increased level of blood pressure, 9,7% - the reduced level high density lipoproteins, 5,8% - raised triglycerides, 22,4% - fasted hyperglycemia, 56,8% - abdominal obesity, 16,8% - metabolic syndrome by IDF criteria (2005). G polymorphism of Ala54Thr FABP2 (71%) are characteristic of the vast majority of representatives Yakut population allele carriage. Frequency of GG genotype was 42,1% (95% CI 35,9-48,6%), AG - 57,9% (95% CI 51,4-64,1%). The association of genotype AG with abdominal obesity was established at OR 1,7 (95% CI 1,01-2,99). Taking into account prevalence in this group of the population of such metabolic disturbances as obesity and the increased level of blood pressure, and also the growing incidence of diabetes type 2, it is necessary to continue search of genes of predisposition to these diseases.