Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients.

Elizabeth R Gerstner,Kyrre E Emblem,Yi-Fen Yen,Jorg Dietrich,Justin T Jordan,Ciprian Catana,Kevin Lou Wenchin,Jacob M Hooker,Dan G Duda,Bruce R Rosen,Jayashree Kalpathy-Cramer,Rakesh K Jain,Tracy T Batchelor

Neuro-oncology advances（2020）

引用 6|浏览51

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摘要

The vascular signature in hypoxic tumor regions indicates a disorganized vasculature which, in most tumors, does not significantly change after bevacizumab treatment. While some tumor regions showed improved vascular efficiency following treatment, bevacizumab did not globally alter hypoxia or normalize tumor vasculature in glioblastoma.

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关键词

antiangiogenic therapy,glioblastoma,hypoxia,vascular normalization

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