Platelet and megakaryocyte CD40L expression in beta-Thalassemic patients

Ornella Morsilli,Raffaella Guerriero,Valentina Lulli,Laura Maffei,Luca Pasquini,Fabio Maria Pulcinelli,Francesco Sorrentino,Marco Gabbianelli

Thrombosis Research（2020）

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摘要

•CD40L is highly expressed both in β-Thalassemic platelets and megakaryocytes.•Aspirin therapy decreases CD40L expression in β-Thalassemic patients.•β-Thalassemic platelets secrete high levels of sCD40L.•sCD40L plasmatic levels are significantly high in β-Thalassemic patients.

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关键词

β-Thalassemia,Platelets,Megakaryocytes,CD40 ligand,Aspirin

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