(Pro)Renin Receptor Blockade Ameliorates Renal Dysfunction-Associated Heart Failure By Suppressing Cardiac Fibrosis But Not By Interfering Autophagy

Akihiro Yoshida,Hiromitsu Kanamori,Genki Naruse,Shingo Minatoguchi, Hisaaki Komaki, Shinya Baba,Junko Naito,Yuka Hayakawa,Masamitsu Iwasa,Yoshihisa Yamada,Atsushi Mikami,Masanori Kawasaki,Kazuhiko Nishigaki,Shinya Minatoguchi

Circulation（2017）

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摘要

Chronic kidney disease (CKD) is a major cardiovascular risk factor because of elevated tissue renin-angiotensin system (RAS) activity in the heart. The (pro)renin receptor ((P)RR), recently identif...

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关键词

Cardiorenal, Heart failure, Renal function, Autophagy, Remodeling

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