Biodegradation of Xenobiotic Compounds

The continuous accumulation of recalcitrant xenobiotic compounds into the ecosystem released from various sources caused a serious global concern. Xenobiotics compounds are carcinogenic, mutagenic, causing teratogenic effect and persist over a long period of time in the environment. Therefore there is an urgent need for the detoxification of these compounds. Biodegradation is a technique that employs natural biological processes to completely degrade toxic contaminants from the environment. The microorganisms possess a wide range of catabolic biodegradation pathways and, thus, use these toxic xenobiotics as the sole source of carbon and energy. Bacteria and fungi are source of xenobiotic degradation. For the development of successful and improved bioremediation processes, understanding of the biochemical and molecular aspects of xenobiotics biodegradation is required. The chapter aims to provide an overview of xenobiotic compounds, factors affecting biodegradation, the metabolic pathways and genetic adaptation in microorganisms for degradation of recalcitrant xenobiotic compounds.