Positive Correlation Between High Breast Cancer Incidence And Ancestry In Colombian Population

Background: Breast cancer is the most frequent cancer in women in the world, however, breast cancer incidence varies substantially world-wide. This disparity can be caused by exposure to reproductive, environmental, lifestyle risk factors, and genetic factors among which is genetic ancestry associated with breast cancer risk. The genetic ancestry is a factor that can influence the risk of many diseases, because of genetic admixture among ancestral source populations from Africa, the Americas and Europe. Colombian population have a trihybrid gentic structure that reflects a early mixed of ancestral populations (indigenous amenricans, europeans and africans), and in the conuntry has been reported a high heterogenety in the breast cancer incidence rates. In this study we investigated how genetic ancestry in admixed colombian population may correlated with the distribution of the breast cancer incidence and mortality rates.