Interplay Between The Pan-Tumor Suppressor Mir-939-5p And The Oncogenic Lncrna-Heih Dually Curbs Hydrogen Sulphide And Nitric Oxide Production In Breast Cancer Cells

Background: Recent light has been cast on the detrimental oncogenic effect of the gasotransmitters, Hydrogen sulfide (H2S) and Nitric Oxide (NO), in Breast Cancer (BC) progression. We and others have recently showed that H2S and NO synthesizing machinery (Cystathione β Synthase (CBS) and Cystathione γ Lyase (CSE), Nitric Oxide Synthase 2/3 (NOS2/3), respectively), were found to be prominently elevated in BC patients. Numerous non-coding RNAs (ncRNAs) especially miRNAs have been acknowledged as upstream regulators for each of those individual enzymes. However, the regulation of H2S and NO synthesizing machinery by lncRNAs has never been investigated. Nonetheless, the hijacking ability of their dual targeting has never been probed in terms of BC. Therefore, the main aim of this study is to pinpoint a novel upstream regulators for NO and H2S synthesizing machinery, to investigate the interplay between ncRNAs and to finally evaluate its effects on BC hallmarks.