Critical and direct involvement of the CD23 stalk region in IgE binding.

Regina Selb,Julia Eckl-Dorna,Teresa E Twaroch,Christian Lupinek,Andrea Teufelberger,Gerhard Hofer,Margarete Focke-Tejkl,Barbara Gepp,Birgit Linhart,Heimo Breiteneder,Adolf Ellinger,Walter Keller,Kenneth H Roux,Rudolf Valenta,Verena Niederberger

Journal of Allergy and Clinical Immunology（2017）

引用 24|浏览15

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摘要

Our results provide a new model for the CD23-IgE interaction. We show that the stalk region of CD23 is crucially involved in IgE binding and that the interaction can be blocked by the therapeutic anti-IgE antibody omalizumab.

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关键词

CD23,allergy,IgE,low-affinity IgE receptor,B cell,allergen

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