Some New C3- And Cs-Symmetrical Trialkylamino-Substituted 1,3,5-Triazines And Their Biological Evaluation

We report the preparation of some new additionally synthesized symmetrical 1,3,5-triazines (TAZ) and the results of biological evaluation of their anti-herpes simplex virus type 1 (anti-HSV-1) activity and cytotoxic activity against Vero cells. All of the new trisubstituted TAZ derivatives 3a-3e showed considerable levels of anti-HSV-1 activity (EC50 = 4.4 similar to 30.3 mu M). Among the tested compounds, two compounds (3c-2 and 3d) that have three 3,4-methylenedioxyphenylalkylamino groups showed low levels of cytotoxicity (CC50> 200 mu M) against Vero cells. On the other hand, the C-3-symmetrical TAZ derivatives 3a-2, 3b-2 and 3e showed considerably high levels of cytotoxicity (CC50 = 8.91 similar to 15.2 mu M). The structure-activity relationships for anti-HSV-1 activity and cytotoxicity of synthesized single-drug type 2,4,6-trisubstituted TAZ derivatives are also discussed.