Chronic Cannabis Users Associated With Lower Bmi And Decreased Obesity Rates

INTRODUCTION: The Western diet leads to an increase in the ratio of omega-6:omega-3 fatty acids, often at a ratio of 20:1 or more. A healthy ratio is anywhere between 1:1 and 3:1. This imbalance disrupts the endocannabinoid system via increased signaling of AEA and 2-AG, which disrupts the homeostatic effects of the CB1 receptor and promotes obesity via increased energy intake and storage7. The use of cannabis has is known to stimulate the CB1 receptors and promote the homeostatic effect, which in turn decreases the increased energy storage associated with their disruption. In this analysis, we aim to evaluate the effect of BMI in cannabis users vs. non-users. A positive correlation between cannabis use and a reduced BMI could lead to cannabis being used as a potential therapy to reduce BMI and promote health in a society in which obesity is rising. METHODS: • BMI of cannabis users range from 23 to 28.7 kg/m2 with a mean of 26 kg/m2. 7. • BMI of non-user range from 24.4 to 29.1 kg/m2 with a mean of 27.5 kg/m2. 7. • Eight out of 9 studies concluded a lower BMI associated with cannabis use7. • Two studies reported longer duration of use correlating with lower BMI7. • Sporadic and high usage of cannabis in young adults was associated with lower obesity rates than those who used less in the same age group7. RESULTS: Eight out of nine studies reviewed by Clark et al. have reported an inverse correlation between cannabis use and BMI. This literature shows statistically significant differences in the BMI of cannabis users vs. non cannabis users. Within this study, a positive correlation was found to exist between the amount of cannabis used in relation to a lower BMI. In one study, evidence was shown that BMI was decreased even in cannabis users who had a higher daily caloric intake in comparison with non-users. CONCLUSION: The evidence shown in this meta- analysis reveals that the CB1 receptors that are stimulated during cannabis use could promote a decrease in energy intake and storage. This potential therapy poses less risk in comparison to other weight loss treatments, such as bariatric surgery or endoscopic procedures. With the number of states legalizing cannabis use increasing, this study suggests that cannabis should be further looked into as a potential therapeutic option for weight loss and strategic lowering of BMI.Figure 1Figure 2Figure 3