New Norneolignan and Bioactive Constituents of Clitoria ternatea

new norneolignan derivative, clitorternalactone ( 1 ), has been isolated from the stems of Clitoria ternatea , together with six known compounds, clitorienolactone A ( 2 ), myricetin 3-glucoside ( 3 ), quercetin 3-glucoside ( 4 ), kaempferol 3-glucoside ( 5 ), taraxerol ( 6 ), and taraxerone ( 7 ). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, compound 1 exhibited cytotoxicities with IC 50 values of 2.54 ± 0.23, 3.68 ± 0.17, and 4.05 ± 0.43 μM, respectively, against DLD-1, CCRF-CEM, and IMR-32 cell lines. In addition, clitorternalactone ( 1 ), clitorienolactone A ( 2 ), quercetin 3-glucoside ( 4 ), and kaempferol 3-glucoside ( 5 ) showed potent inhibition with IC 50 values of 3.05 ± 0.12, 5.44 ± 0.46, 10.20 ± 0.69, and 13.57 ± 0.36 μM, respectively, against LPS-induced NO generation.