The pharmacokinetic and pharmacodynamic relationship between apraglutide and citrulline: a randomized, placebo-controlled, double-blind study in healthy volunteers

Rationale: Plasma citrulline, a biomarker for enterocytic mass, is increased after GLP-2 analogs administration. Pharmacokinetic/pharmacodynamic (PK/PD) relationships between apraglutide, a novel long-acting GLP-2 analog in development for short bowel syndrome, and citrulline were evaluated.