Subanalysis of the CYP-GUIDES Trial: CYP2D6 Functional Stratification and Operational Timeline Selection

Gualberto Ruaño,Joseph Tortora,Saskia Robinson,Seth Baker,Theodore Holford,Andrew Winokur,John W. Goethe

Psychiatry Research（2021）

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摘要

•The CYP-GUIDES Trial assessed length of hospitalization in major depressive disorder.•It compared drug treatment guided by CYP2D6 functional status versus standard care.•CYP2D6 guidance reduced hospitalization length of stay and drug utilization.•CYP2D6 functional stratification found guidance effect to be on sub-normal patients.•Sub-normal CYP2D6 function represents a treatable pharmacogenetic vulnerability.

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关键词

psychotropic utilization,CYP2D6 pharmacogenetics,major depressive disorder,psychiatric hospitalization,clinical decision support

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