High efficiency biosynthesis of O-polysaccharide-based vaccines against extraintestinal pathogenic Escherichia coli

Xiaolong Jiang,Jing Bai,Jian Yuan,Huijing Zhang,Gege Lu,Yuhui Wang,Lingyan Jiang,Bin Liu,Lei Wang,Di Huang,Lu Feng

Carbohydrate Polymers（2021）

引用 9|浏览4

暂无评分

摘要

•Efficient production of OPS-based glycoconjugates were achieved by metabolic reprogramming.•Constitutive expression is superior for high quality glycoconjugates production.•Highest yield (38.6 mg L−1) with high sugar content was achieved.•Glycoconjugate vaccines conferred significant protection against ExPEC infection.

查看译文

关键词

Glyco-optimized chassis strain,Glycoconjugate vaccine,O-polysaccharide,ExPEC,Glycosylation efficiency,Sugar to protein ratio

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要