Design and synthesis of nature-inspired chromenopyrroles as potential modulators of mitochondrial metabolism
MEDICINAL CHEMISTRY RESEARCH(2020)
摘要
Chromenopyrrole derivatives with multiple stereocenters and variable ring fusion pattern are found in many natural products and biologically appealing molecules. By employing a build/couple/pair strategy, we have recently reported on the discovery of a serendipitous cascade to access a diverse collection of chromenopyrroles. This protocol features a one-pot cascade that includes the generation of azomethine ylide and intramolecular [3 + 2]-cycloaddition. Phenotypic screening of the developed pilot library enabled the identification of chemical probes that efficiently suppress mitochondrial membrane potential, elevate reactive oxygen species content, and deplete ATP content in a hepatoma cell line (Hepa1-6), without affecting the proliferation of T- or B-cells. This selective targeting represents a new approach for the treatment of cancer.
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关键词
Chromenopyrroles,Phenotypic screening,Mitochondrial metabolism,Anticancer activity,Hepatoma cells,Immunotherapy
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