DNA sequencing using nanopores and kinetic proofreading
QUANTITATIVE BIOLOGY(2020)
摘要
We discuss the feasibility of using a nanopore sandwich device to implement the principle of kinetic proofreading to discriminate incorrect hybridizing oligonucleotides on a target DNA or RNA. We propose a method of sequencing DNA or RNA using this approach. The design parameters for such a DNA sequencer are estimated from the Hopfield-Ninio theory of kinetic proofreading and Schrödinger’s first-passage-time distribution function.
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关键词
DNA sequencing,nanopore sequencing,biosensing using kinetics
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