Subjective Sleep Quality In Amnestic Mild Cognitive Impairment Elderly And Its Possible Relationship With Plasma Amyloid-Beta

Study objectivesTo investigate the extent to which sleep quality associated with plasma A beta levels in amnestic mild cognitive impairment (aMCI) elderly. MethodsA total of 172 cognitively normal (NC) elderly and 133 aMCI elderly were included in this study. For the evaluation of sleep quality, the Pittsburgh Sleep Quality Index (PSQI) was used. Levels of plasma A beta were determined by the sandwich enzyme-linked immunosorbent assay technique. Multivariable linear regression analysis was applied to evaluate associations between sleep quality and plasma A beta levels after adjusting potential confounders. ResultsCompared to NC subjects, participants with aMCI had a higher global PSQI score (8.72 +/- 3.87 vs. 7.10 +/- 3.07, p < 0.001). The global PSQI score was positively associated with plasma A beta(42) level in the aMCI group (beta = 0.063, 95% CI 0.001-0.125, and p = 0.049) but not in the NC group (p > 0.05). Additionally, a higher global PSQI score was associated with a higher plasma A beta(42)/A beta(40) ratio in both NC (beta = 0.010, 95% CI 0.003-0.016, and p = 0.003) and aMCI groups (beta = 0.012, 95% CI 0.005-0.018, and p < 0.001). The association between global PSQI score and plasma A beta(42)/A beta(40) ratio was stronger in individuals with aMCI relative to the NC subjects (beta = 0.076 vs. 0.030, p for interaction = 0.023). ConclusionPoor sleep quality was associated with plasma A beta(42) and A beta(42)/A beta(40) ratio, with a stronger effect among individuals with aMCI. A better understanding of the role of sleep in plasma A beta levels in aMCI patients could lead to effective sleep-based intervention against the risk of Alzheimer's disease.