Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases As Targets Worth Investigating for Effective Therapy of Toxoplasmosis

Mariana Galvao Ferrarini,Lindice Mitie Nisimura,Richard Marcel Bruno Moreira Girard,Mayke Bezerra Alencar, Mariana Sayuri Ishikawa Fragoso,Carlla Assis Araujo-Silva, Alan de Almeida Veiga,Ana Paula Ressetti Abud,Sheila Cristina Nardelli,Rossiane C. Vommaro,Ariel Mariano Silber, Marie France-Sagot,Andrea Rodrigues Avila

MSphere（2021）

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摘要

Currently, the drugs used for toxoplasmosis have severe toxicity to human cells, and the treatment still lacks effective and safer alternatives. The search for novel drug targets is timely.

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关键词

toxoplasmosis,DCA,metabolism

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