Endothelial Nox4 dysfunction aggravates atherosclerosis by inducing endoplasmic reticulum stress and soluble epoxide hydrolase

•Direct evidence of upregulated sEH induced by EC Nox4 dysfunction in promoting atherosclerosis.•Nox4 dysfunction induces ER stress in ECs.•ER stress and sEH regulates each other in ECs to enhance inflammation.•ER stress inhibitor 4-PBA alleviates atherosclerosis induced by EC Nox4 dysfunction.•Inhibiting ER stress and sEH could be beneficial in atherosclerosis.