Peroxisomes and pancreatic beta-cell lipo-dysfunction

•Peroxisomes play a key role in the initial metabolism of palmitate and other long chain fatty acids.•Targeted knockdown of the Pex11β gene led to peroxisome depletion in insulin secreting cells•Peroxisome depletion reversed the inhibitory effect of palmitate on insulin secretion.•Peroxisomes play an independent role in lipid mediated beta-cell lipo-dysfunction.