[Toll-like Receptor Agonists in Radiation Protection].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae(2020)
摘要
Ionizing radiation causes the massive apoptosis of human tissue cells,leading to dysfunction of the gastrointestinal tract and hematopoietic system.Thus,high-efficiency,low-toxicity radiation protection drugs are urgently needed.Toll-like receptor agonists have been developed based on the anti-apoptotic mechanism of tumor cells in recent years,which exert their radioprotective effects by activating downstream pathways,mainly nuclear factor-κB.Here we elucidate several agonists of Toll-like receptors involved in radiation protection,with an attempt to inform the research and development of new radiation protection agents.
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关键词
Toll-like receptor agonist,nuclear factor-κB,radiation protection
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