Palmitoyl-KVK-L-ascorbic acid conjugate improves matrix abnormality associated with skin aging via epigenetic regulation

Journal of Dermatological Science（2021）

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摘要

•DNA methyltransferase 1 (DNMT1) is implicated in epigenetic skin aging.•DVP modulated DNMT1 and extracellular matrix in vitro and in vivo.•Skin anti-aging epigenetic mechanism of DVP was revealed.•Potential of DNMT1 inhibitors as skin anti-aging agents was validated.

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关键词

DNMT,UV,DVP

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