Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure

Vincenzo R. Lobbia, Christina Trueba Sanchez,Hugo van Ingen

Journal of Molecular Biology（2021）

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摘要

•We propose 7 ways for nucleosome binding proteins to affect higher order structure.•Choices on nucleosomal array conditions impact protein binding and overall structure.•Chromatin phase separation is driven by a range of interactions to the nucleosome.

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关键词

Linker histone,HP1,Phase separation,Nucleosomal arrays,Oligonucleosomes

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