Fatal Pyrrolizidine Alkaloid Poisoning of Infants Caused by Adulterated Senecio Coronatus.
Forensic science international(2021)
摘要
Senecio coronatus (known as izonkozonko and ubulibazi in Zulu) is commonly used in traditional medicine in South Africa as purification purgative and enemas for infants during weaning. We show for the first time that this species does not contain pyrrolizidine alkaloids and that reported cases of fatal hepatic sinusoidal obstruction syndrome in infants were caused by wrongly identified Senecio species containing large amounts of retrorsine-N-oxide. A validated ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection and quantitation of pyrrolizidine alkaloids is described.
更多查看译文
关键词
Senecio coronatus,LCMS,UPLC-MS,MS,Retrorsine-N-oxide,Pyrrolizidine alkaloids,Traditional medicine
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要