Melanin Production in Coelomycetous Agents of Black Grain Eumycetoma.
Transactions of the Royal Society of Tropical Medicine and Hygiene(2021)
摘要
BACKGROUND:Eumycetoma is a fungal infection characterised by the formation of black grains by causative agents. The melanin biosynthetic pathways used by the most common causative agents of black-grain mycetoma are unknown and unravelling them could identify potential new therapeutic targets.METHOD:Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors.RESULTS:In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis.CONCLUSION:Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.
更多查看译文
关键词
Falciformispora senegalensis,Falciformispora tompkinsii,Medicopsis romeroi,melanin,mycetoma,Trematosphaeria grisea
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要