Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration alone in intracranial infections

•Intraventricular (IVT) application of colistin to control multidrug-resistant Gram-negative bacteria.•Preliminary data on the pharmacokinetics of colistin after IVT administration alone.•Effective concentrations of colistin in CSF and microbiological cure were achieved.•Personalised regimen: a lower dose may be adequate for pathogens with a lower MIC.