Determinants of quality of life and psychosocial adjustment to pediatric inflammatory bowel disease: A systematic review focused on Crohn's disease

•Regardless of disease state, abdominal pain predicts poor quality of life, depression and disability.•Internalized symptoms predict poor quality of life, disability and school difficulties.•Illness' consequences, emotional impact and intrusiveness predict poor quality of life and distress.•Parental stress predicts poor quality of life, internalizing and externalizing symptoms in children.•Self-esteem, relationships, social and school adjustment are still rarely explored.