Analysis of the Association of Haplotypes with Alzheimer's Disease and Mild Cognitive Impairment in the Russian Population

Haplotype associations of 894 DNA samples of elderly people from the Russian population of Tomsk were analyzed using 49 SNPs (single nucleotide polymorphisms). As the analyzed markers, SNPs were selected that showed an association with Alzheimer's disease or variability of cognitive abilities in genome-wide association studies. As a result of the analysis, blocks on chromosomes 1, 2, 6, 8, 11, 19, and 20 were identified. Significant associations were shown, taking into account 50 000 permutations, for haplotypes localized on chromosomes 1 and 19 in the genesCR1andAPOE,APOC1, respectively. Our results confirm the role of theAPOEandCR1genes in the pathogenesis of Alzheimer's disease in the Russian population.