One-pot synthesis of beta-ketosulfones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water

A novel, facile and efficient strategy for the one-pot synthesis of beta-ketosulfones from readily available sulfonyl chloride, hydrazine hydrate and vinyl azides is described. The reaction proceeded very smoothly affording diverse beta-ketosulfones in moderate to good yields. This new procedure has the advantages of environmental benign, easy and simple operation, low cost and wide tolerance of functional groups, which provides a highly fascinating protocol to access beta-ketosulfones. (C) 2020 Elsevier Ltd. All rights reserved.