Power Calculations In Randomised Controlled Trials Of Inflammatory Bowel Disease

ow naded rom http:urnals.lw w om ajg by hD M fePH bH 4TIm qeA+lpW IIBonhQ l60Etnn9T1vLQ W J/+R 2O 4jt58 on 077/2021 Downloadedfromhttp://journals.lww.com/ajgbyBhDMf5ePHKbH4TTImqenVA+lpWIIBvonhQl60Etgtdnn9T1vLQWJq/+R2O4Kjt58on07/07/2021 clinical presentation, IBD course and treatment including dietary therapy, mental health disorder history and outcome as of last follow up. RESULTS: Ten patients were identified with IBD and restrictive eating patterns. Age at diagnosis was 7–16 years, 8 females and 2 males. 7 had CD, 2 UC, and 1 IBDU. Five patients had known mental health conditions at time of IBD diagnosis (anxiety, ADHD, Major Depressive Disorder). 2/10 patients had formal ED diagnosis before their IBD diagnosis. 8/10 patients developed symptoms of ED after IBD diagnosis and met criteria for ED NOS. 6/8 (75%) patients with ED NOS after IBD diagnosis were exposed to diet therapy: 2 EEN, 4 EEN with subsequent SCD. 3/6 had a prior mental health diagnosis. ED NOS appeared within a median of 22 months from diet therapy initiation (range 2 months–3 years). Of the 2 patients with a previous ED diagnosis, 1 was exposed to diet therapy. Both patients had persistent ED symptoms despite remission with biologic therapy. Of the 6 patients with ED NOS after IBD diagnosis who were exposed to diet therapy, 4 had persistent ED despite clinical remission with biologic therapy. Lastly, both patients who developed ED NOS after IBD diagnosis and were not exposed to diet therapy had persistent ED NOS symptomatology despite remission with biologics. CONCLUSION: Eight out of 10 children with IBD and ED disorder symptoms diagnosed before or after IBD diagnosis had persistent ED symptoms despite successful IBD therapy with biologics. The overlap between IBD and ED merits further study to outline the incidence of ED in IBD, possible risk factors for persistent ED and understand patient outcomes. In our case series, ED symptoms persisted in patients regardless of whether nutrition therapy was used or not.