Effect of Moderate Endurance Training and Consumption of Rosa Canina L. Extract on Liver Enzyme Profile in Male Rats

Background and purpose: Inactivity due to the mechanization of work is a growing health concern in many countries. It increases the risk of many diseases such as fatty liver, obesity and diabetes. There are evidences on the effect of exercise on levels of liver enzymatic parameters. Herbal products appear to be useful in managing some diseases, such as fatty liver. Materials and methods: This experimental study investigated the response of liver enzyme indices, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT), and lipid profile (total triglyceride and total cholesterol) in rat liver after eight weeks of endurance training and consumption of Rosa canina L. extract. Thirty-six rats were randomly divided into four groups: control-saline, training-saline, control-Rosa canina L. and Rosa canina L.+training. Liver enzyme levels, triglycerides and total cholesterol levels were measured. Results: ANOVA test showed that AST and ALT levels decreased significantly in training-saline (P=0.024 and P=0.002, respectively) and control-Rosa canina L. (P=0.004 and P=0.001, respectively) groups compared to control-saline group. The interaction effect of training and Rosa canina L. caused a significant decrease in AST and ALT levels compared to other groups (P=0.001). ALP levels reduced in training-saline (P=0.008), control-Rosa canina L. (P=0.002), and Rosa canina L.+ training (P=0.001) compared with control-saline. Analysis of GGT showed no significant difference between the groups (P=0.172). Endurance training and the extract of Rosa canina L. improved the levels of triglycerides and total cholesterol. Conclusion: Endurance training in combination with Rosa canina L. extract can have a significant effect on reducing liver enzyme indicators, triglycerides, and total cholesterol.