Monitoring Fibrin Polymerization Effects On Whole Blood Coagulation Using A Microfluidic Dielectric Sensor
2020 IEEE SENSORS(2020)
摘要
This paper reports on the use of a microfluidic dielectric sensor, termed ClotChip, for monitoring the fibrin polymerization effects on whole blood coagulation. The ClotChip sensor readout captures the temporal variation in the normalized real part of the blood dielectric permittivity at 1MHz as it undergoes coagulation. A new readout parameter, S-max, is identified in the ClotChip readout curve, which represents the maximum permittivity slope after a permittivity peak is reached. Experiments based on ex vivo treatment of whole blood samples with H-Gly-Pro-Arg-Pro-OH (GPRP) - a fibrin-polymerization inhibitor - demonstrate that S-max decreases with increasing GPRP concentrations corresponding to higher levels of fibrin inhibition. Furthermore, S-max is shown to exhibit a strong positive correlation (Pearson's r = 0.883, p < 0.001, n = 12) with the alpha-angle readout parameter of rotational thromboelastometry - a clinical, viscoelastometry-based, comprehensive assay of blood coagulation. This work shows the ClotChip potential as a point-of-care platform for rapid assessment of fibrin-polymerization defects and their impact on the overall hemostatic status.
更多查看译文
关键词
Dielectric coagulometry, dielectric spectroscopy, microfluidics, fibrinogen, fibrin polymerization, whole blood coagulation
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要