Patient-Reported Outcomes Of Breast Cancer Patients During The Covid-19 Outbreak In The Epicenter Of China: A Cross-Sectional Survey Study.

Purpose: We aimed to analyze the psychological status of breast cancer (BC) patients in the epicenter of theCOVID-19 pandemic Patients and Methods: A total of 658 individuals were recruited from multiple breast cancer centers in HubeiProvince Online questionnaires were conducted and included demographic information, clinical features, and fourpatient-reported outcomes (PROs) scales (GAP-7, PHQ-9, ISI, and IES-R) Multivariable logistic regression analysis was designed to identify potential factors on mental health outcomes Results: Questionnaires were collected from February 16 to 19, 2020, the peak time point of COVID-19 outbreak inChina 46 2% of BC patients had to modify planned necessary anticancer treatment during the outbreak 8 9% and9 3% of patients reported severe anxiety and severe depression, respectively 20 8% and 4 0% of patients showedsevere distress and insomnia, respectively Multivariable logistic regression analysis demonstrated poor generalcondition, shorter duration after BC diagnosis, aggressive BC molecular subtypes, and close contact with COVID-19patients as independent factors associated with anxiety Poor general condition and CVC (central venous catheter)flushing delay were factors independently associated with depression In terms of insomnia, poor general condition was the only associated independent factor Poor physical condition and treatment discontinuation were underlyingrisk factors for distress based on multivariable analysis Conclusion: High rates of anxiety, depression, distress, and insomnia were observed in patients with breast cancerduring the COVID-19 outbreak Special attention should be paid to the psychological status of breast cancerpatients, especially those with poor general condition, treatment discontinuation, aggressive molecular subtypes, and metastatic breast cancer