Increased plasma apolipoprotein M levels impair triglyceride turnover in mice

Background and Aims: Increased plasma triglyceride levels are commonly observed in patients with obesity, type 2 diabetes and metabolic syndrome. The efficiency of current available treatments is however limited, and a more comprehensive understanding of the underlying pathological processes is thus demanded. Lipases and lipoproteins play a central role in maintaining a balanced triglyceride turnover. A heterogenous lipoprotein fraction carries apolipoprotein M (apoM) which in return binds Sphingosine-1-Phosphate (S1P). Both mediators play a role in energy metabolism. Their exact contribution is however elusive, and thus addressed by the present study.