Cd39(+) Regulatory T Cells Attenuate Lipopolysaccharide-Induced Acute Lung Injury Via Autophagy And The Erk/Fos Pathway
FRONTIERS IN IMMUNOLOGY(2021)
摘要
Acute respiratory distress syndrome (ARDS) is characterized by an uncontrollable cytokine storm, which is associated with high mortality due to lack of effective treatment. Regulatory T cells (Tregs) play an indispensable role in maintaining immune homeostasis and CD39 is considered as a functional cell marker of Tregs. In this study, we aimed to evaluate the effect of CD39(+) Tregs on acute lung injury (ALI) and investigate the frequency of CD39(+) Tregs in ARDS patients. We found that after lipopolysaccharide (LPS) treatment, CD39(-/-) mice exhibited more severe inflammation and wild type (WT) mice exhibited a decreased frequency of CD39(+) Tregs in the peripheral blood. Furthermore, CD39(+) Tregs had a protective effect on LPS-induced inflammation in vitro and the adoptive transfer of CD39(+) Tregs had a therapeutic effect on ALI in vivo. We further sought to explore the mechanisms that affect CD39 expression on Tregs. LPS-induced inflammation in the lung impaired the immunosuppressive effect of Tregs via the autophagy-mediated downregulation of CD39. In addition, CD39 induced the expression of itself in Tregs via activating the ERK1/2-FOS pathway. Consistent with this finding, the frequency of CD39(+) Tregs was also decreased in the peripheral blood of ARDS patients and was positively correlated with disease severity. Our results suggested that the adoptive transfer of CD39(+) Tregs may provide a novel method for the clinical prevention and treatment of ARDS.
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关键词
acute respiratory distress syndrome, CD39, regulatory T cells, acute lung injury, adoptive transfer, autography, ERK, FOS
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